RAB43 antibody (AA 90-170)

Catalog No. ABIN7230894

The Rabbit Polyclonal anti-RAB43 antibody (ABIN7230894) specifically detects RAB43 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for RAB43 antibody (AA 90-170) (ABIN7230894)

Target: RAB43 (RAB43, Member RAS Oncogene Family (RAB43))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAB43 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-RAB43 Antibody

Binding Specificity: AA 90-170

Purpose: Rabbit Anti-RAB43 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of RAB43 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human RAB43 protein at AA range: 90-170

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for RAB43

Target: RAB43 (RAB43, Member RAS Oncogene Family (RAB43))

Alternative Name: RAB43

Background: Ras-related protein Rab-43, Ras-related protein Rab-41RAB43 (RAB43, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are RAB geranylgeranylation and Golgi-to-ER retrograde transport. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S. ureus and M. uberculosis.

Molecular Weight: 23kD

Gene ID: 339122

UniProt: Q86YS6