RASA4 antibody (AA 100-180)

Catalog No. ABIN7230954

This Rabbit Polyclonal antibody specifically detects RASA4 in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for RASA4 antibody (AA 100-180) (ABIN7230954)

Target: RASA4 (RAS P21 Protein Activator 4 (RASA4))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RASA4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-RASA4 Antibody

Binding Specificity: AA 100-180

Purpose: Rabbit Anti-RASL2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of RASL2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human RASL2 protein at AA range: 100-180

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for RASA4

Target: RASA4 (RAS P21 Protein Activator 4 (RASA4))

Alternative Name: RASL2

Background: Ras GTPase-activating protein 4, Calcium-promoted Ras inactivator, Ras p21 protein activator 4, RasGAP-activating-like protein 2RASA4 (RAS P21 Protein Activator 4) encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for RASA4.

Molecular Weight: 88kD

Gene ID: 10156

UniProt: O43374