Retinoblastoma Binding Protein 8 antibody

Catalog No. ABIN7223948

This Rabbit Polyclonal antibody specifically detects Retinoblastoma Binding Protein 8 in ELISA and IHC (p). It exhibits reactivity toward Human and Mouse.

Quick Overview for Retinoblastoma Binding Protein 8 antibody (ABIN7223948)

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Retinoblastoma Binding Protein 8 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Retinoblastoma Binding Protein 8 Antibody

Purpose: CtIP Polyclonal Antibody

Specificity: CtIP Polyclonal Antibody detects endogenous levels of CtIP protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human CtIP around the non-phosphorylation site of S664

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:300), ELISA (1:5000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for Retinoblastoma Binding Protein 8

Target: Retinoblastoma Binding Protein 8 (RBBP8)

Alternative Name: CtIP

Background: Rabbit Anti-CtIP Polyclonal Antibody,RBBP8, CTIP, DNA endonuclease RBBP8, CtBP-interacting protein, CtIP, Retinoblastoma-binding protein 8, RBBP-8, Retinoblastoma-interacting protein and myosin-like, RIM, Sporulation in the absence of SPO11 protein 2 homolog, SAE2,The protein encoded by RBBP8 (RB binding protein 8, endonuclease) is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that RBBP8 may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for RBBP8. More transcript variants exist, but their full-length natures have not been determined.,DNA endonuclease RBBP8

Gene ID: 5932

UniProt: Q99708

Pathways: Cell Division Cycle, DNA Damage Repair