ARHGAP24 antibody (AA 550-630)

Catalog No. ABIN7231038

The Rabbit Polyclonal anti-ARHGAP24 antibody (ABIN7231038) specifically detects ARHGAP24 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for ARHGAP24 antibody (AA 550-630) (ABIN7231038)

Target: ARHGAP24 (rho GTPase Activating Protein 24 (ARHGAP24))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARHGAP24 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-ARHGAP24 Antibody

Binding Specificity: AA 550-630

Purpose: Rabbit Anti-RHG24 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of RHG24 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human RHG24 protein at AA range: 550-630

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for ARHGAP24

Target: ARHGAP24 (rho GTPase Activating Protein 24 (ARHGAP24))

Alternative Name: RHG24

Background: Rho GTPase-activating protein 24, Filamin-A-associated RhoGAP, FilGAP, RAC1- and CDC42-specific GTPase-activating protein of 72 kDa, RC-GAP72, Rho-type GTPase-activating protein 24, RhoGAP of 73 kDa, Sarcoma antigen NY-SAR-88, p73RhoGAPARHGAP24 (Rho GTPase Activating Protein 24) is a Protein Coding gene. Diseases associated with ARHGAP24 include Glomerulosclerosis, Focal Segmental, 1 and Atypical Autism. Among its related pathways are G-protein signaling_Regulation of RAC1 activity and p75 NTR receptor-mediated signalling. ARHGAP24 encodes a Rho-GTPase activating protein, which is specific for the small GTPase family member Rac. Binding of the encoded protein by filamin A targets it to sites of membrane protrusion, where it antognizes Rac. This results in suppression of lamellae formation and promotion of retraction to regulate cell polarity. Alternative splicing results in multiple transcript variants.

Molecular Weight: 82kD

Gene ID: 83478

UniProt: Q8N264

Pathways: Regulation of Cell Size, Positive Regulation of Response to DNA Damage Stimulus