RNF6 antibody (AA 470-550)

Catalog No. ABIN7231114

This Rabbit Polyclonal antibody specifically detects RNF6 in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for RNF6 antibody (AA 470-550) (ABIN7231114)

Target: RNF6 (RING Finger Protein 6 (RNF6))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-RNF6 Antibody

Binding Specificity: AA 470-550

Purpose: Rabbit Anti-RNF6 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of RNF6 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human RNF6 protein at AA range: 470-550

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for RNF6

Target: RNF6 (RING Finger Protein 6 (RNF6))

Alternative Name: RNF6

Background: E3 ubiquitin-protein ligase RNF6, RING-type E3 ubiquitin transferase RNF6RNF6 (Ring Finger Protein 6) is a Protein Coding gene. Diseases associated with RNF6 include Esophageal Cancer and Squamous Cell Carcinoma. Among its related pathways are Class I MHC mediated antigen processing and presentation and Androgen receptor signaling pathway. The protein encoded by RNF6 contains a RING-H2 finger motif. Deletions and mutations in RNF6 were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed.

Molecular Weight: 75kD

Gene ID: 6049

UniProt: Q9Y252

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Cell Size