S100A12 antibody (AA 290-370)

Catalog No. ABIN7229764

The Rabbit Polyclonal anti-S100A12 antibody is suitable to detect S100A12 in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for S100A12 antibody (AA 290-370) (ABIN7229764)

Target: S100A12 (S100 Calcium Binding Protein A12 (S100A12))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This S100A12 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-S100A12 Antibody

Binding Specificity: AA 290-370

Purpose: Rabbit Anti-MRP6 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of MRP6 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human MRP6 protein at AA range: 290-370

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for S100A12

Target: S100A12 (S100 Calcium Binding Protein A12 (S100A12))

Alternative Name: MRP6

Background: Multidrug resistance-associated protein 6, ATP-binding cassette sub-family C member 6, Anthracycline resistance-associated protein, Multi-specific organic anion transporter E, MOAT-EABCC6 (ATP Binding Cassette Subfamily C Member 6) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling. The protein encoded by ABCC6 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in ABCC6 cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for ABCC6.

Molecular Weight: 165kD

Gene ID: 368

UniProt: O95255

Pathways: Toll-Like Receptors Cascades, S100 Proteins