SCO2 antibody (AA 181-230)

Catalog No. ABIN7231290

The Rabbit Polyclonal anti-SCO2 antibody (ABIN7231290) specifically detects SCO2 in WB and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for SCO2 antibody (AA 181-230) (ABIN7231290)

Target: SCO2 (SCO2 Cytochrome C Oxidase Assembly Protein (SCO2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCO2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SCO2 Antibody

Binding Specificity: AA 181-230

Purpose: Rabbit Anti-SCO2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of SCO2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human SCO2 protein at AA range: 181-230

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for SCO2

Target: SCO2 (SCO2 Cytochrome C Oxidase Assembly Protein (SCO2))

Alternative Name: SCO2

Background: Protein SCO2 homolog, mitochondrialCytochrome c oxidase (COX) catalyzes the transfer of electrons from cytochrome c to molecular oxygen, which helps to maintain the proton gradient across the inner mitochondrial membrane that is necessary for aerobic ATP production. Human COX is a multimeric protein complex that requires several assembly factors, SCO2 encodes one of the COX assembly factors. The encoded protein is a metallochaperone that is involved in the biogenesis of cytochrome c oxidase subunit II. Mutations in SCO2 are associated with fatal infantile encephalocardiomyopathy and myopia 6.

Molecular Weight: 29kD

Gene ID: 9997

UniProt: O43819

Pathways: Transition Metal Ion Homeostasis, Warburg Effect