SCRIB antibody

Catalog No. ABIN7231292

The Rabbit Polyclonal anti-SCRIB antibody is suitable to detect SCRIB in samples from Human and Mouse. It has been validated for WB and ELISA.

Quick Overview for SCRIB antibody (ABIN7231292)

Target: SCRIB (Scribbled Homolog (SCRIB))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCRIB antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SCRIB Antibody

Purpose: Rabbit Anti-SCRIB Polyclonal Antibody

Specificity: The antibody detects endogenous levels of SCRIB protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human SCRIB protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for SCRIB

Target: SCRIB (Scribbled Homolog (SCRIB))

Alternative Name: SCRIB

Background: Protein scribble homolog, Scribble, hScrib, Protein LAP4SCRIB gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

Molecular Weight: 179kD

Gene ID: 23513

UniProt: Q14160

Pathways: Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Tube Formation, Synaptic Vesicle Exocytosis, Asymmetric Protein Localization