SH2B3 antibody

Catalog No. ABIN7231342

The Rabbit Polyclonal anti-SH2B3 antibody (ABIN7231342) specifically detects SH2B3 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for SH2B3 antibody (ABIN7231342)

Target: SH2B3 (SH2B Adaptor Protein 3 (SH2B3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SH2B3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SH2B3 Antibody

Purpose: Rabbit Anti-SH2B3 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of SH2B3 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human SH2B3 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for SH2B3

Target: SH2B3 (SH2B Adaptor Protein 3 (SH2B3))

Alternative Name: SH2B3

Background: SH2B adapter protein 3, Lymphocyte adapter protein, Lymphocyte-specific adapter protein Lnk, Signal transduction protein LnkSH2B3 (SH2B Adaptor Protein 3) encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in SH2B3 have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for SH2B3.

Molecular Weight: 63kD

Gene ID: 10019

UniProt: Q9UQQ2