NEU2 antibody

Catalog No. ABIN7229972

The Rabbit Polyclonal anti-NEU2 antibody is suitable to detect NEU2 in samples from Human, Rat and Mouse. It has been validated for WB and ELISA.

Quick Overview for NEU2 antibody (ABIN7229972)

Target: NEU2 (Sialidase 2 (Cytosolic Sialidase) (NEU2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NEU2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-NEU2 Antibody

Purpose: Rabbit Anti-NEU2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of NEU2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human NEU2 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for NEU2

Target: NEU2 (Sialidase 2 (Cytosolic Sialidase) (NEU2))

Alternative Name: NEU2

Background: Vasopressin-neurophysin 2-copeptin, AVP-NPIIAVP encodes a member of the vasopressin/oxytocin family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the neuropeptide hormone arginine vasopressin, and two other peptides, neurophysin 2 and copeptin. Arginine vasopressin is a posterior pituitary hormone that is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI). This gene is present in a gene cluster with the related gene oxytocin on chromosome 20.

Molecular Weight: 18kD

Gene ID: 551

UniProt: P01185

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development