SIRPB1 antibody (AA 200-280)

Catalog No. ABIN7214046

The Rabbit Polyclonal anti-SIRPB1 antibody is suitable to detect SIRPB1 in samples from Human. It has been validated for WB and ELISA.

Quick Overview for SIRPB1 antibody (AA 200-280) (ABIN7214046)

Target: SIRPB1 (Signal-Regulatory Protein beta 1 (SIRPB1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIRPB1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SIRPB1 Antibody

Binding Specificity: AA 200-280

Purpose: Rabbit Anti-CD172b Polyclonal Antibody

Specificity: CD172b Polyclonal Antibody detects endogenous levels of CD172b protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human CD172b at AA range: 200-280

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:5000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for SIRPB1

Target: SIRPB1 (Signal-Regulatory Protein beta 1 (SIRPB1))

Alternative Name: CD172b

Background: SIRPB1, Signal-regulatory protein beta-1, SIRP-beta-1, CD172 antigen-like family member B, CD antigen CD172bSignal regulatory protein beta 1 encoded by SIRPB1 is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for SIRPB1.

Molecular Weight: 48kD

Gene ID: 10326

UniProt: O00241