SLAMF7 antibody

Catalog No. ABIN7231382

The Rabbit Polyclonal anti-SLAMF7 antibody (ABIN7231382) specifically detects SLAMF7 in WB and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for SLAMF7 antibody (ABIN7231382)

Target: SLAMF7 (SLAM Family Member 7 (SLAMF7))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLAMF7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SLAMF7 Antibody

Purpose: Rabbit Anti-SLAF7 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of SLAF7 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human SLAF7 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for SLAMF7

Target: SLAMF7 (SLAM Family Member 7 (SLAMF7))

Alternative Name: SLAF7

Background: SLAM family member 7, CD2 subset 1, CD2-like receptor-activating cytotoxic cells, CRACC, Membrane protein FOAP-12, Novel Ly9, Protein 19A, CD_antigen: CD319SLAMF7 (SLAM Family Member 7) is a Protein Coding gene. Diseases associated with SLAMF7 include Multiple Myeloma. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K. In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion. In LPS-activated monocytes negatively regulates production of proinflammatory cytokines. Isoform 3 does not mediate any NK cell activation.

Molecular Weight: 36kD

Gene ID: 57823

UniProt: Q9NQ25