SMC1B antibody (AA 110-190)

Catalog No. ABIN7231408

The Rabbit Polyclonal anti-SMC1B antibody (ABIN7231408) specifically detects SMC1B in WB and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for SMC1B antibody (AA 110-190) (ABIN7231408)

Target: SMC1B (Structural Maintenance of Chromosomes 1B (SMC1B))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMC1B antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SMC1B Antibody

Binding Specificity: AA 110-190

Purpose: Rabbit Anti-SMC1B Polyclonal Antibody

Specificity: The antibody detects endogenous levels of SMC1B protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human SMC1B protein at AA range: 110-190

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for SMC1B

Target: SMC1B (Structural Maintenance of Chromosomes 1B (SMC1B))

Alternative Name: SMC1B

Background: Structural maintenance of chromosomes protein 1B, SMC protein 1B, SMC-1-beta, SMC-1BSMC1B (Structural Maintenance Of Chromosomes 1B) is a Protein Coding gene. Among its related pathways are Meiosis and Oocyte meiosis. An important paralog of this gene is SMC1A. Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity).

Molecular Weight: 135kD

Gene ID: 27127

UniProt: Q8NDV3