TAO Kinase 3 antibody (AA 500-580)

Catalog No. ABIN7215504

The Rabbit Polyclonal anti-TAO Kinase 3 antibody (ABIN7215504) specifically detects TAO Kinase 3 in WB, ELISA and IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for TAO Kinase 3 antibody (AA 500-580) (ABIN7215504)

Target: TAO Kinase 3 (TAOK3)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAO Kinase 3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-TAO Kinase 3 Antibody

Binding Specificity: AA 500-580

Purpose: Rabbit Anti-JIK Polyclonal Antibody

Specificity: JIK Polyclonal Antibody detects endogenous levels of JIK protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human JIK at AA range: 500-580

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IHC 1:50-300,ELISA 1:2000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for TAO Kinase 3

Target: TAO Kinase 3 (TAOK3)

Alternative Name: JIK

Background: TAOK3, DPK, JIK, KDS, MAP3K18, Serine/threonine-protein kinase TAO3, Cutaneous T-cell lymphoma-associated antigen HD-CL-09, CTCL-associated antigen HD-CL-09, Dendritic cell-derived protein kinase, JNK/SAPK-inhibitory kinase, Jun kinase-inhiTAOK3 is a Protein Coding gene. Serine/threonine-protein kinase TAO3 acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). Diseases associated with TAOK3 include kabuki syndrome 1. Among its related pathways are MAPK signaling pathway and p38 MAPK signaling pathway (Pathway Interaction Database). Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TAOK1.

Molecular Weight: 110kD

Gene ID: 51347

UniProt: Q9H2K8