tau antibody (acLys174)

Catalog No. ABIN7231708

This Rabbit Polyclonal antibody specifically detects tau in WB, ELISA and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for tau antibody (acLys174) (ABIN7231708)

Target: tau (tau Protein)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This tau antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-tau Antibody

Binding Specificity: acLys174

Purpose: Rabbit Anti-Tau (Acetyl Lys174) Polyclonal Antibody

Specificity: The antibody detects endogenous levels of Tau when Acetyl occurs at Lys174

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human Tau (Acetyl Lys174) protein at AA range: 174

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IF/ICC1:100-500,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for tau

Target: tau (tau Protein)

Alternative Name: Tau

Background: Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tauMAPT encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. MAPT (Microtubule Associated Protein Tau) is a Protein Coding gene. Diseases associated with MAPT include Pick Disease and Supranuclear Palsy, Progressive. Among its related pathways are Alzheimers Disease Pathway and Reelin signaling pathway.

Molecular Weight: 50-85kD

Gene ID: 4137

UniProt: P10636