TGIF2 antibody

Catalog No. ABIN7231776

This Rabbit Polyclonal antibody specifically detects TGIF2 in ELISA and WB. It exhibits reactivity toward Human and Mouse.

Quick Overview for TGIF2 antibody (ABIN7231776)

Target: TGIF2 (TGFB-Induced Factor Homeobox 2 (TGIF2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TGIF2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-TGIF2 Antibody

Purpose: Rabbit Anti-TGIF2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of TGIF2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human TGIF2 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for TGIF2

Target: TGIF2 (TGFB-Induced Factor Homeobox 2 (TGIF2))

Alternative Name: TGIF2

Background: Homeobox protein TGIF2, 5'-TG-3'-interacting factor 2, TGF-beta-induced transcription factor 2, TGFB-induced factor 2TGIF2 (TGFB Induced Factor Homeobox 2) is a Protein Coding gene. Diseases associated with TGIF2 include Holoprosencephaly 4. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and mir34a and TGIF2 in osteoclastogenesis. The protein encoded by TGIF2 is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. TGIF2 is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between TGIF2 and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene.

Molecular Weight: 26kD

Gene ID: 60436

UniProt: Q9GZN2