TRIP12 antibody (AA 950-1030)

Catalog No. ABIN7231912

The Rabbit Polyclonal anti-TRIP12 antibody (ABIN7231912) specifically detects TRIP12 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for TRIP12 antibody (AA 950-1030) (ABIN7231912)

Target: TRIP12 (Thyroid Hormone Receptor Interactor 12 (TRIP12))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIP12 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TRIP12 Antibody

Binding Specificity: AA 950-1030

Purpose: Rabbit Anti-TRIPC Polyclonal Antibody

Specificity: The antibody detects endogenous levels of TRIPC protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human TRIPC protein at AA range: 950-1030

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for TRIP12

Target: TRIP12 (Thyroid Hormone Receptor Interactor 12 (TRIP12))

Alternative Name: TRIPC

Background: E3 ubiquitin-protein ligase TRIP12, E3 ubiquitin-protein ligase for Arf, ULF, HECT-type E3 ubiquitin transferase TRIP12, Thyroid receptor-interacting protein 12, TR-interacting protein 12, TRIP-12TRIP12 (Thyroid Hormone Receptor Interactor 12) is a Protein Coding gene. Diseases associated with TRIP12 include Non-Syndromic Intellectual Disability and Chronic Dacryocystitis. Among its related pathways are Class I MHC mediated antigen processing and presentation and Ubiquitin mediated proteolysis. The protein encoded by TRIP12 is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53.

Molecular Weight: 219kD

Gene ID: 9320

UniProt: Q14669

Pathways: Nuclear Hormone Receptor Binding