TTR antibody

Catalog No. ABIN7212312

This Mouse Monoclonal antibody specifically detects TTR in WB, IF and IHC (p). It exhibits reactivity toward Human.

Quick Overview for TTR antibody (ABIN7212312)

Target: TTR (Transthyretin (TTR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TTR antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 1D7

Product Details anti-TTR Antibody

Purpose: TTR Mouse Monoclonal Antibody (1D7)

Specificity: The antibody detects endogenous TTR protein.

Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen

Immunogen: Recombinant Protein of TTR

Isotype: IgG1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:50-1:2000).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for TTR

Target: TTR (Transthyretin (TTR))

Alternative Name: TTR

Background: Mouse Anti-TTR Mouse Monoclonal Antibody (1D7),Transthyretin, ATTR, Prealbumin, TBPA,TTR (transthyretin) encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein, it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in TTR have been reported, most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.,Transthyretin (ATTR) (Prealbumin) (TBPA)

Molecular Weight: observerd band 16kDa

Gene ID: 7276

UniProt: P02766

Pathways: Hormone Transport