Tropomyosin antibody (AA 101-150)

Catalog No. ABIN7231914

The Rabbit Polyclonal anti-Tropomyosin antibody is suitable to detect Tropomyosin in samples from Human, Rat and Mouse. It has been validated for WB and ELISA.

Quick Overview for Tropomyosin antibody (AA 101-150) (ABIN7231914)

Target: Tropomyosin (TPM1) (Tropomyosin 1 (Alpha) (TPM1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Tropomyosin antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Tropomyosin Antibody

Binding Specificity: AA 101-150

Purpose: Rabbit Anti-Tropomyosin α Polyclonal Antibody

Specificity: The antibody detects endogenous levels of Tropomyosin α

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human Tropomyosin alpha protein at AA range: 101-150

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:10000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Tropomyosin

Target: Tropomyosin (TPM1) (Tropomyosin 1 (Alpha) (TPM1))

Alternative Name: Tropomyosin alpha

Background: Tropomyosin alpha-1 chain, Alpha-tropomyosin, Tropomyosin-1TPM1 (Tropomyosin 1) is a Protein Coding gene. Diseases associated with TPM1 include Cardiomyopathy, Hypertrophic, 3 and Cardiomyopathy, Dilated, 1E. Among its related pathways are Striated Muscle Contraction and Dilated cardiomyopathy (DCM). This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in TPM1 are associated with type 3 familial hypertrophic cardiomyopathy.

Molecular Weight: 38kD

Gene ID: 7168

UniProt: P09493

Pathways: Regulation of Actin Filament Polymerization