UBR1 antibody (AA 790-870)

Catalog No. ABIN7217434

The Rabbit Polyclonal anti-UBR1 antibody (ABIN7217434) specifically detects UBR1 in WB, ELISA, IHC and IF. The antibody is reactive with Human and Mouse samples.

Quick Overview for UBR1 antibody (AA 790-870) (ABIN7217434)

Target: UBR1 (Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-UBR1 Antibody

Binding Specificity: AA 790-870

Purpose: Rabbit Anti-Ubr1 Polyclonal Antibody

Specificity: Ubr1 Polyclonal Antibody detects endogenous levels of Ubr1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human Ubr1 at AA range: 790-870

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,ELISA 1:20000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for UBR1

Target: UBR1 (Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1))

Alternative Name: Ubr1

Background: UBR1, E3 ubiquitin-protein ligase UBR1, N-recognin-1, Ubiquitin-protein ligase E3-alpha-1, Ubiquitin-protein ligase E3-alpha-IThe N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by UBR1, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. E3 ubiquitin-protein ligase UBR1 described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome.

Molecular Weight: 200kD

Gene ID: 197131

UniProt: Q8IWV7