ULBP2 antibody

Catalog No. ABIN7229878

The Rabbit Polyclonal anti-ULBP2 antibody (ABIN7229878) specifically detects ULBP2 in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for ULBP2 antibody (ABIN7229878)

Target: ULBP2 (UL16 Binding Protein 2 (ULBP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ULBP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-ULBP2 Antibody

Purpose: Rabbit Anti-N2DL2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of N2DL2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human N2DL2 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for ULBP2

Target: ULBP2 (UL16 Binding Protein 2 (ULBP2))

Alternative Name: N2DL2

Background: UL16-binding protein 2, ALCAN-alpha, NKG2D ligand 2, N2DL-2, NKG2DL2, Retinoic acid early transcript 1HULBP2 encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. ULBP2 is located in a cluster of multiple MHC class I-related genes on chromosome 6. ULBP2 (UL16 Binding Protein 2) is a Protein Coding gene. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and p53 Pathway (RnD).

Molecular Weight: 27kD

Gene ID: 80328

UniProt: Q9BZM5