ZFHX3 antibody (AA 730-810)

Catalog No. ABIN7222610

This Rabbit Polyclonal antibody specifically detects ZFHX3 in ELISA, IHC and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for ZFHX3 antibody (AA 730-810) (ABIN7222610)

Target: ZFHX3 (Zinc Finger Homeobox 3 (ZFHX3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZFHX3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-ZFHX3 Antibody

Binding Specificity: AA 730-810

Purpose: Rabbit Anti-ATBF1 Polyclonal Antibody

Specificity: ATBF1 Polyclonal Antibody detects endogenous levels of ATBF1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human ATBF1 at AA range: 730-810

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300,ELISA 1:10000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for ZFHX3

Target: ZFHX3 (Zinc Finger Homeobox 3 (ZFHX3))

Alternative Name: ATBF1

Background: ZFHX3, ATBF1, Zinc finger homeobox protein 3, AT motif-binding factor, AT-binding transcription factor 1, Alpha-fetoprotein enhancer-binding protein, Zinc finger homeodomain protein 3, ZFH-3ZFHX3 encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). ZFHX3 is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene.

Gene ID: 463

UniProt: Q15911

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development