ABI1 antibody (AA 180-230)

Catalog No. ABIN7265359

This Rabbit Polyclonal antibody specifically detects ABI1 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for ABI1 antibody (AA 180-230) (ABIN7265359)

Target: ABI1 (Abl-Interactor 1 (ABI1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABI1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-ABI1 Antibody

Binding Specificity: AA 180-230

Purpose: ABI1 Rabbit pAb

Sequence: PMSGRGTLGR NTPYKTLEPV KPPTVPNDYM TSPARLGSQH SPGRTASLNQ R

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 180-230 of human ABI1 (NP_001012770).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ABI1

Target: ABI1 (Abl-Interactor 1 (ABI1))

Alternative Name: ABI1

Background: This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10,11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14.,ABI1,ABI-1,ABLBP4,E3B1,NAP1BP,SSH3BP,SSH3BP1,Signal Transduction,G protein signaling,Signal Transduction,Kinase,Cell Biology & Developmental Biology,Cell Cycle,Growth factor,EGF,ABI1

Molecular Weight: 35-55kDa

Gene ID: 10006

UniProt: Q8IZP0

Pathways: RTK Signaling, Response to Water Deprivation, ER-Nucleus Signaling