ACVR1 antibody

Catalog No. ABIN7265415

The Rabbit Monoclonal anti-ACVR1 antibody (ABIN7265415) specifically detects ACVR1 in WB. The antibody is reactive with Human samples.

Quick Overview for ACVR1 antibody (ABIN7265415)

Target: ACVR1 (ACRV1) (Activin Receptor Type I (ACRV1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ACVR1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ACVR1 Antibody

Purpose: ACVR1 Rabbit mAb

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant protein of human ACVR1.

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ACVR1

Target: ACVR1 (ACRV1) (Activin Receptor Type I (ACRV1))

Alternative Name: ACVR1

Background: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.,ACVR1, ACTRI, ACVR1A, ACVRLK2, ALK2, FOP, SKR1, TSRI, activin receptor type-1,Epigenetics & Nuclear Signaling,Signal Transduction,Kinase,Cell Biology & Developmental Biology,Apoptosis,Cytoskeleton,Microfilaments,Extracellular Matrix,Bone,Stem Cells,Cardiovascular,Angiogenesis,ACVR1

Molecular Weight: 57kDa

Gene ID: 90

UniProt: Q04771