CMKLR1 antibody (AA 250-350)

Catalog No. ABIN7266326

The Rabbit Polyclonal anti-CMKLR1 antibody has been validated for WB. It is suitable to detect CMKLR1 in samples from Human.

Quick Overview for CMKLR1 antibody (AA 250-350) (ABIN7266326)

Target: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CMKLR1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CMKLR1 Antibody

Binding Specificity: AA 250-350

Purpose: CMKLR1 Rabbit pAb

Sequence: NRLAKTKKPF KIIVTIIITF FLCWCPYHTL NLLELHHTAM PGSVFSLGLP LATALAIANS CMNPILYVFM GQDFKKFKVA LFSRLVNALS EDTGHSSYPS H

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 250-350 of human CMKLR1 (NP_001135815.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CMKLR1

Target: CMKLR1 (Chemokine-Like Receptor 1 (CMKLR1))

Alternative Name: CMKLR1

Background: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i/G(o and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2, TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis PubMed:27716822. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2 and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism.,CMKLR1,CHEMERINR,ChemR23,DEZ,RVER1,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),Cell Biology & Developmental Biology,Cytoskeleton,Extracellular Matrix,Bone,CMKLR1

Molecular Weight: 42kDa

Gene ID: 1240

UniProt: Q99788