CHCHD2 antibody (AA 75-145)

Catalog No. ABIN7266448

This Rabbit Polyclonal antibody specifically detects CHCHD2 in WB, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for CHCHD2 antibody (AA 75-145) (ABIN7266448)

Target: CHCHD2 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2 (CHCHD2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHCHD2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Grade: KO Validated

Product Details anti-CHCHD2 Antibody

Binding Specificity: AA 75-145

Purpose: [KO Validated] CHCHD2 Rabbit pAb

Sequence: TLGHAITGGF SGGSNAEPAR PDITYQEPQG TQPAQQQQPC LYEIKQFLEC AQNQGDIKLC EGFNEVLKQC R

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 75-145 of human CHCHD2 (NP_057223.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CHCHD2

Target: CHCHD2 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2 (CHCHD2))

Alternative Name: CHCHD2

Background: The protein encoded by this gene belongs to a class of eukaryotic CX(9)C proteins characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form disulfide linkages that define a CHCH fold. In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport chain. In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen. In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis. In response to apoptotic stimuli, mitochondrial levels of this protein decrease, allowing BCL2-associated X protein to oligomerize and activate the caspase cascade. Pseudogenes of this gene are found on multiple chromosomes. Alternative splicing results in multiple transcript variants.,CHCHD2,C7orf17,MNRR1,NS2TP,PARK22,Cell Biology & Developmental Biology,CHCHD2

Molecular Weight: 15kDa

Gene ID: 51142

UniProt: Q9Y6H1