Cytosolic Arginine Sensor For mTORC1 Subunit 1 (CASTOR1) antibody

Catalog No. ABIN7266667

This Rabbit Polyclonal antibody specifically detects Cytosolic Arginine Sensor For mTORC1 Subunit 1 in WB, IF and IHC. It exhibits reactivity toward Human.

Quick Overview for Cytosolic Arginine Sensor For mTORC1 Subunit 1 (CASTOR1) antibody (ABIN7266667)

Target: Cytosolic Arginine Sensor For mTORC1 Subunit 1 (CASTOR1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

Product Details

Purpose: CASTOR1 Rabbit pAb

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant protein of human CASTOR1.

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details

Target: Cytosolic Arginine Sensor For mTORC1 Subunit 1 (CASTOR1)

Alternative Name: CASTOR1

Background: Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway.,GATSL3,CASTOR1

Molecular Weight: 36kDa

Gene ID: 652968

UniProt: Q8WTX7