DNER antibody (AA 140-240)

Catalog No. ABIN7266727

This Rabbit Polyclonal antibody specifically detects DNER in WB and IF. It exhibits reactivity toward Human.

Quick Overview for DNER antibody (AA 140-240) (ABIN7266727)

Target: DNER (delta/notch-Like EGF Repeat Containing (DNER))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNER antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-DNER Antibody

Binding Specificity: AA 140-240

Purpose: DNER Rabbit pAb

Sequence: PATGWTESMA PRQLQPVPAT QEPDKILPRS QATVTLPTWQ PKTGQKVVEM KWDQVEVIPD IACGNASSNS SAGGRLVSFE VPQNTSVKIR QDATASLILL W

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 140-240 of human DNER (NP_620711.3).

Isotype: IgG

Application Details

Application Notes: WB,1:200 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for DNER

Target: DNER (delta/notch-Like EGF Repeat Containing (DNER))

Alternative Name: DNER

Background: DNER (Delta/Notch-like EGF-related receptor), also known as BET (brain-specific EGF-like transmembrane protein), is a type I transmembrane glycoprotein of the Notch/Delta family . In the mouse, DNER has been detected as 90, 120 and 150 kDa forms which are probably variably glycosylated .Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis.DNER associates with protein tyrosine phosphatase zeta (PTP zeta ), which is the receptor of pleiotrophin (PTN). PTP zeta -PTN-DNER signaling has been implicated in the regulation of neuritogenesis. Expression of DNER in glioblastoma stem-like cells inhibits formation of neurospheres in vitro, while in vivo it induces differentiation and inhibits growth of xenografts, thus acting as a tumor suppressor.,DNER,UNQ26,bet,Neuroscience,Stem Cells,DNER

Molecular Weight: 78kDa

Gene ID: 92737

UniProt: Q8NFT8

Pathways: Skeletal Muscle Fiber Development