E2F5 antibody (AA 197-346)

Catalog No. ABIN7266878

The Rabbit Polyclonal anti-E2F5 antibody has been validated for WB. It is suitable to detect E2F5 in samples from Human.

Quick Overview for E2F5 antibody (AA 197-346) (ABIN7266878)

Target: E2F5

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This E2F5 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-E2F5 Antibody

Binding Specificity: AA 197-346

Purpose: E2F5 Rabbit pAb

Sequence: QLEVPIPEMG QNGQKKYQIN LKSHSGPIHV LLINKESSSS KPVVFPVPPP DDLTQPSSQS LTPVTPQKSS MATQNLPEQH VSERSQALQQ TSATDISSAG SISGDIIDEL MSSDVFPLLR LSPTPADDYN FNLDDNEGVC DLFDVQILNY

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 197-346 of human E2F5 (NP_001942.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for E2F5

Target: E2F5

Alternative Name: E2F5

Background: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms.,E2F5,E2F-5,Epigenetics & Nuclear Signaling,Transcription Factors,Signal Transduction,ErbB-HER Signaling Pathway,E2F5

Molecular Weight: 20kDa/37kDa

Gene ID: 1875

UniProt: Q15329