NEDD4-2 antibody

Catalog No. ABIN7266882

This anti-NEDD4-2 antibody is a Rabbit Monoclonal antibody detecting NEDD4-2 in WB. Suitable for Human.

Quick Overview for NEDD4-2 antibody (ABIN7266882)

Target: NEDD4-2 (NEDD4L) (E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This NEDD4-2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NEDD4-2 Antibody

Purpose: NEDD4L Rabbit mAb

Cross-Reactivity: Human

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human NEDD4L

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NEDD4-2

Target: NEDD4-2 (NEDD4L) (E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))

Alternative Name: NEDD4L

Background: This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012],NEDD4-2, NEDD4.2, PVNH7, RSP5, hNEDD4-2,Cell Biology & Developmental Biology,Epigenetics & Nuclear Signaling,Protein phosphorylation,Ubiquitin,Ubiquitin_Ubiquitin-Proteasome Signaling Pathway,NEDD4L

Molecular Weight: 130kDa

Gene ID: 23327

UniProt: Q96PU5

Pathways: Negative Regulation of Transporter Activity