EXOSC10 antibody (AA 586-885)

Catalog No. ABIN7267062

This anti-EXOSC10 antibody is a Rabbit Polyclonal antibody detecting EXOSC10 in WB. Suitable for Human.

Quick Overview for EXOSC10 antibody (AA 586-885) (ABIN7267062)

Target: EXOSC10 (Exosome Component 10 (EXOSC10))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EXOSC10 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-EXOSC10 Antibody

Binding Specificity: AA 586-885

Purpose: EXOSC10 Rabbit pAb

Sequence: VAAGVKKSGP LPSAERLENV LFGPHDCSHA PPDGYPIIPT SGSVPVQKQA SLFPDEKEDN LLGTTCLIAT AVITLFNEPS AEDSKKGPLT VAQKKAQNIM ESFENPFRMF LPSLGHRAPV SQAAKFDPST KIYEISNRWK LAQVQVQKDS KEAVKKKAAE QTAAREQAKE ACKAAAEQAI SVRQQVVLEN AAKKRERATS DPRTTEQKQE KKRLKISKKP KDPEPPEKEF TPYDYSQSDF KAFAGNSKSK VSSQFDPNKQ TPSGKKCIAA KKIKQSVGNK SMSFPTGKSD RGFRYNWPQR

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 586-885 of human EXOSC10 (NP_001001998.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for EXOSC10

Target: EXOSC10 (Exosome Component 10 (EXOSC10))

Alternative Name: EXOSC10

Background: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs, and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR and/or Ig variable region somatic hypermutation (SHM by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity. EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPHOSPH6 with the RNA exosome involved in the maturation of 5.8S rRNA.,EXOSC10,PM-Scl,PM/Scl-100,PMSCL,PMSCL2,RRP6,Rrp6p,p2,p3,p4,Epigenetics & Nuclear Signaling,RNA Binding,Immunology & Inflammation,EXOSC10

Molecular Weight: 98kDa/100kDa

Gene ID: 5394

UniProt: Q01780