FAR1 antibody (AA 1-220)

Catalog No. ABIN7267158

The Rabbit Polyclonal anti-FAR1 antibody (ABIN7267158) specifically detects FAR1 in WB. The antibody is reactive with Human samples.

Quick Overview for FAR1 antibody (AA 1-220) (ABIN7267158)

Target: FAR1 (Fatty Acyl CoA Reductase 1 (FAR1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAR1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FAR1 Antibody

Binding Specificity: AA 1-220

Purpose: FAR1 Rabbit pAb

Sequence: MVSIPEYYEG KNVLLTGATG FLGKVLLEKL LRSCPKVNSV YVLVRQKAGQ TPQERVEEVL SGKLFDRLRD ENPDFREKII AINSELTQPK LALSEEDKEV IIDSTNIIFH CAATVRFNEN LRDAVQLNVI ATRQLILLAQ QMKNLEVFMH VSTAYAYCNR KHIDEVVYPP PVDPKKLIDS LEWMDDGLVN DITPKLIGDR PNTYIYTKAL AEYVVQQEGA

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human FAR1 (NP_115604.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for FAR1

Target: FAR1 (Fatty Acyl CoA Reductase 1 (FAR1))

Alternative Name: FAR1

Background: The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13.,FAR1,MLSTD2,PFCRD,SDR10E1,Cancer,Signal Transduction,Endocrine & Metabolism,Lipid Metabolism,FAR1

Molecular Weight: 59kDa

Gene ID: 84188

UniProt: Q8WVX9