GIT2 antibody (AA 450-510)

Catalog No. ABIN7267315

This Rabbit Polyclonal antibody specifically detects GIT2 in WB. It exhibits reactivity toward Human.

Quick Overview for GIT2 antibody (AA 450-510) (ABIN7267315)

Target: GIT2 (G Protein-Coupled Receptor Kinase Interactor 2 (GIT2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GIT2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GIT2 Antibody

Binding Specificity: AA 450-510

Purpose: GIT2 Rabbit pAb

Sequence: ASRLEKQNST PESDYDNTPN DMEPDGMGSS RKGRQRSMVW PGDGLVPDTA EPHVAPSPTL P

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 450-510 of human GIT2 (NP_476511.1).

Isotype: IgG

Application Details

Application Notes: WB,1:200 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for GIT2

Target: GIT2 (G Protein-Coupled Receptor Kinase Interactor 2 (GIT2))

Alternative Name: GIT2

Background: This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.,GIT2,CAT-2,CAT2,PKL,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),Kinase,Cell Biology & Developmental Biology,Cytoskeleton,Actins,GIT2

Molecular Weight: 52kDa, 70-84kDa

Gene ID: 9815

UniProt: Q14161

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling