IGF1R antibody (pTyr1131, pTyr1146)

Catalog No. ABIN7267901

The Rabbit Polyclonal anti-IGF1R antibody has been validated for WB. It is suitable to detect IGF1R in samples from Human.

Quick Overview for IGF1R antibody (pTyr1131, pTyr1146) (ABIN7267901)

Target: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IGF1R antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IGF1R Antibody

Binding Specificity: pTyr1131, pTyr1146

Purpose: Phospho-INSR-Y1146/IGF1R-Y1131 Rabbit pAb

Cross-Reactivity: Human

Characteristics: Phosphorylated Antibodies

Purification: Affinity purification

Immunogen: A synthetic phosphorylated peptide around Y1146 of human INSR and Y1131 of human IGF1R.

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for IGF1R

Target: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Alternative Name: IGF1R/INSR

Background: This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],INSR/IGF1R,Protein phosphorylation,Protein phosphorylation,Protein phosphorylation,IGF1R/INSR

Molecular Weight: 155kDa

Gene ID: 3643, 3480

UniProt: P06213, P08069

Pathways: RTK Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy