CD130/gp130 antibody (AA 678-857)

Catalog No. ABIN7268004

The Rabbit Polyclonal anti-CD130/gp130 antibody (ABIN7268004) specifically detects CD130/gp130 in WB, IHC and IF. The antibody is reactive with Human samples.

Quick Overview for CD130/gp130 antibody (AA 678-857) (ABIN7268004)

Target: CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD130/gp130 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-CD130/gp130 Antibody

Binding Specificity: AA 678-857

Purpose: IL6ST Rabbit pAb

Sequence: PSISSSDENE SSQNTSSTVQ YSTVVHSGYR HQVPSVQVFS RSESTQPLLD SEERPEDLQL VDHVDGGDGI LPRQQYFKQN CSQHESSPDI SHFERSKQVS SVNEEDFVRL KQQISDHISQ SCGSGQMKMF QEVSAADAFG PGTEGQVERF ETVGMEAATD EGMPKSYLPQ TVRQGGYMPQ

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 678-857 of human IL6ST (NP_001177910.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CD130/gp130

Target: CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))

Alternative Name: IL6ST

Background: The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17.,IL6ST,CD130,CDW130,GP130,IL-6RB,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Immunology & Inflammation,CD markers,Cytokines,IL-6 Receptor Signaling Pathway,Cardiovascular,Heart,Hypertrophy,IL6ST

Molecular Weight: 103kDa

Gene ID: 3572

UniProt: P40189

Pathways: JAK-STAT Signaling, Cellular Glucan Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Cancer Immune Checkpoints