Cytokeratin 18 antibody (AA 127-430)

Catalog No. ABIN7268098

This Rabbit Polyclonal antibody specifically detects Cytokeratin 18 in WB, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for Cytokeratin 18 antibody (AA 127-430) (ABIN7268098)

Target: Cytokeratin 18 (KRT18) (Keratin 18 (KRT18))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cytokeratin 18 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-Cytokeratin 18 Antibody

Binding Specificity: AA 127-430

Purpose: Cytokeratin 18 (KRT18) Rabbit pAb

Sequence: SHYFKIIEDL RAQIFANTVD NARIVLQIDN ARLAADDFRV KYETELAMRQ SVENDIHGLR KVIDDTNITR LQLETEIEAL KEELLFMKKN HEEEVKGLQA QIASSGLTVE VDAPKSQDLA KIMADIRAQY DELARKNREE LDKYWSQQIE ESTTVVTTQS AEVGAAETTL TELRRTVQSL EIDLDSMRNL KASLENSLRE VEARYALQME QLNGILLHLE SELAQTRAEG QRQAQEYEAL LNIKVKLEAE IATYRRLLED GEDFNLGDAL DSSNSMQTIQ KTTTRRIVDG KVVSETNDTK VLRH

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 127-430 of human Cytokeratin 18 (KRT18) (NP_000215.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Cytokeratin 18

Target: Cytokeratin 18 (KRT18) (Keratin 18 (KRT18))

Alternative Name: KRT18

Background: KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.,KRT18,CK-18,CYK18,K18,keratin 18,Epigenetics & Nuclear Signaling,RNA Binding,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Cytoskeleton,Intermediate Filaments,Extracellular Matrix,Cytokeratin,Keratin,KRT18

Molecular Weight: 48kDa

Gene ID: 3875

UniProt: P05783

Pathways: Apoptosis, Caspase Cascade in Apoptosis