LAMa4 antibody (AA 1-100)

Catalog No. ABIN7268183

The Rabbit Polyclonal anti-LAMa4 antibody is suitable to detect LAMa4 in samples from Human. It has been validated for WB.

Quick Overview for LAMa4 antibody (AA 1-100) (ABIN7268183)

Target: LAMa4 (Laminin, alpha 4 (LAMa4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LAMa4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-LAMa4 Antibody

Binding Specificity: AA 1-100

Purpose: LAMA4 Rabbit pAb

Sequence: MALSSAWRSV LPLWLLWSAA CSRAASGDDN AFPFDIEGSS AVGRQDPPET SEPRVALGRL PPAAEVQCPC HCHPAGAPAP PRAVPHSSFS LSPPLSSPQC

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human LAMA4 (NP_001098678.1).

Isotype: IgG

Application Details

Application Notes: WB,1:200 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for LAMa4

Target: LAMa4 (Laminin, alpha 4 (LAMa4))

Alternative Name: LAMA4

Background: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. This gene encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost. Laminin, alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and gamma chains. The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, Tissue-specific utilization of alternative polyA-signal has been described in literature.,LAMA4,CMD1JJ,LAMA3,LAMA4*-1,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Cytoskeleton,Extracellular Matrix,Neuroscience,LAMA4

Molecular Weight: 12kDa/201kDa/202kDa

Gene ID: 3910

UniProt: Q16363

Pathways: Brown Fat Cell Differentiation