LAT antibody (pTyr171)

Catalog No. ABIN7268273

The Rabbit Polyclonal anti-LAT antibody has been validated for WB. It is suitable to detect LAT in samples from Human.

Quick Overview for LAT antibody (pTyr171) (ABIN7268273)

Target: LAT (Linker For Activation of T Cells (LAT))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LAT antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-LAT Antibody

Binding Specificity: pTyr171

Purpose: Phospho-LAT-Y171 Rabbit pAb

Sequence: DDYVN

Cross-Reactivity: Human

Characteristics: Phosphorylated Antibodies

Purification: Affinity purification

Immunogen: A synthetic phosphorylated peptide around Y171 of human LAT (NP_001014987.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for LAT

Target: LAT (Linker For Activation of T Cells (LAT))

Alternative Name: LAT

Background: The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.,LAT,LAT1,pp36,IMD52,Signal Transduction,G protein signaling,Signal Transduction,Immunology & Inflammation,T Cell Receptor Signaling Pathway,Protein phosphorylation,LAT

Molecular Weight: 24kDa/27kDa/28kDa

Gene ID: 27040

UniProt: O43561

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway