MAML2 antibody (AA 750-850)

Catalog No. ABIN7268410

This Rabbit Polyclonal antibody specifically detects MAML2 in WB and IF. It exhibits reactivity toward Human.

Quick Overview for MAML2 antibody (AA 750-850) (ABIN7268410)

Target: MAML2 (Mastermind-Like 2 (MAML2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAML2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-MAML2 Antibody

Binding Specificity: AA 750-850

Purpose: MAML2 Rabbit pAb

Sequence: NQQLMGKKQT LQRQIMEQKQ QLLLQQQMLA DAEKIAPQDQ INRHLSRPPP DYKDQRRNVG NMQPTAQYSG GSSTISLNSN QALANPVSTH TILTPNSSLL S

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 750-850 of human MAML2 (NP_115803.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MAML2

Target: MAML2 (Mastermind-Like 2 (MAML2))

Alternative Name: MAML2

Background: The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed.,MAML2,MAM-3,MAM2,MAM3,MLL-MAML2,Epigenetics & Nuclear Signaling,Signal Transduction,Cell Biology & Developmental Biology,Notch Signaling Pathway,Stem Cells,MAML2

Gene ID: 84441

UniProt: Q8IZL2