MBD2 antibody

Catalog No. ABIN7268491

This Rabbit Monoclonal antibody specifically detects MBD2 in WB. It exhibits reactivity toward Human.

Quick Overview for MBD2 antibody (ABIN7268491)

Target: MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MBD2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MBD2 Antibody

Purpose: MBD2 Rabbit mAb

Cross-Reactivity: Mouse

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human MBD2

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MBD2

Target: MBD2 (Methyl-CpG Binding Domain Protein 2 (MBD2))

Alternative Name: MBD2

Background: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011],DMTase, NY-CO-41,Epigenetics & Nuclear Signaling,MBD2

Molecular Weight: 29,43kDa

Gene ID: 8932

UniProt: Q9UBB5

Pathways: Chromatin Binding