NLRP1 antibody (AA 1000-1100)

Catalog No. ABIN7268935

This Rabbit Polyclonal antibody specifically detects NLRP1 in WB, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for NLRP1 antibody (AA 1000-1100) (ABIN7268935)

Target: NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-NLRP1 Antibody

Binding Specificity: AA 1000-1100

Purpose: NLRP1 Rabbit pAb

Sequence: TGEMSNSTSS LKRQRLGSER AASHVAQANL KLLDVSKIFP IAEIAGKSHE ESSPEVVPVE LLCVPSPASQ GDLHTKPLGT DDDFWGPTGP VATEVVDKEK N

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1000-1100 of human NLRP1 (NP_001028225.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NLRP1

Target: NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))

Alternative Name: NLRP1

Background: This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.,NLRP1,AIADK,CARD7,CIDED,CLR17.1,DEFCAP,DEFCAP-L/S,MSPC,NAC,NALP1,PP1044,SLEV1,VAMAS1,Cell Biology & Developmental Biology,Apoptosis,Caspases,NLRP1

Molecular Weight: 46kDa/83kDa/154-165kDa

Gene ID: 22861

UniProt: Q9C000

Pathways: Positive Regulation of Endopeptidase Activity, Inflammasome