ORC2 antibody (AA 458-577)

Catalog No. ABIN7269109

This Rabbit Polyclonal antibody specifically detects ORC2 in WB. It exhibits reactivity toward Human.

Quick Overview for ORC2 antibody (AA 458-577) (ABIN7269109)

Target: ORC2 (Origin Recognition Complex Subunit 2 (ORC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ORC2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ORC2 Antibody

Binding Specificity: AA 458-577

Purpose: ORC2 Rabbit pAb

Sequence: TSYENSLLVK QSGSLPLSSL THVLRSLTPN ARGIFRLLIK YQLDNQDNPS YIGLSFQDFY QQCREAFLVN SDLTLRAQLT EFRDHKLIRT KKGTDGVEYL LIPVDNGTLT DFLEKEEEEA

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 458-577 of human ORC2 (NP_006181.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ORC2

Target: ORC2 (Origin Recognition Complex Subunit 2 (ORC2))

Alternative Name: ORC2

Background: The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate.,ORC2,ORC2L,Epigenetics & Nuclear Signaling,Nuclear Receptor Signaling,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,ORC2

Molecular Weight: 65kDa

Gene ID: 4999

UniProt: Q13416