PDE3A antibody (AA 380-660)

Catalog No. ABIN7269301

This Rabbit Polyclonal antibody specifically detects PDE3A in WB, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for PDE3A antibody (AA 380-660) (ABIN7269301)

Target: PDE3A (phosphodiesterase 3A, cGMP-Inhibited (PDE3A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE3A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-PDE3A Antibody

Binding Specificity: AA 380-660

Purpose: PDE3A Rabbit pAb

Sequence: LLSTQLTFQA IHKPRVNPVT SLSENYTCSD SEESSEKDKL AIPKRLRRSL PPGLLRRVSS TWTTTTSATG LPTLEPAPVR RDRSTSIKLQ EAPSSSPDSW NNPVMMTLTK SRSFTSSYAI SAANHVKAKK QSRPGALAKI SPLSSPCSSP LQGTPASSLV SKISAVQFPE SADTTAKQSL GSHRALTYTQ SAPDLSPQIL TPPVICSSCG RPYSQGNPAD EPLERSGVAT RTPSRTDDTA QVTSDYETNN NSDSSDIVQN EDETECLREP LRKASACSTY A

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 380-660 of human PDE3A (NP_000912.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PDE3A

Target: PDE3A (phosphodiesterase 3A, cGMP-Inhibited (PDE3A))

Alternative Name: PDE3A

Background: This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.,HTNB,CGI-PDE,CGI-PDE A,CGI-PDE-A,PDE3A,Signal Transduction,PDE3A

Molecular Weight: 125kDa

Gene ID: 5139

UniProt: Q14432

Pathways: cAMP Metabolic Process