PHKA1 antibody (AA 600-820)

Catalog No. ABIN7269367

This Rabbit Polyclonal antibody specifically detects PHKA1 in WB. It exhibits reactivity toward Human.

Quick Overview for PHKA1 antibody (AA 600-820) (ABIN7269367)

Target: PHKA1 (phosphorylase Kinase, alpha 1 (Muscle) (PHKA1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHKA1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PHKA1 Antibody

Binding Specificity: AA 600-820

Purpose: PHKA1 Rabbit pAb

Sequence: QTGKLSEFLT TSCCTHLSFM DPGPEGKLYS EDYDDNYDYL ESGNWMNDYD STSHARCGDE VARYLDHLLA HTAPHPKLAP TSQKGGLDRF QAAVQTTCDL MSLVTKAKEL HVQNVHMYLP TKLFQASRPS FNLLDSPHPR QENQVPSVRV EIHLPRDQSG EVDFKALVLQ LKETSSLQEQ ADILYMLYTM KGPDWNTELY NERSATVREL LTELYGKVGE I

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 600-820 of human PHKA1 (NP_001116142.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PHKA1

Target: PHKA1 (phosphorylase Kinase, alpha 1 (Muscle) (PHKA1))

Alternative Name: PHKA1

Background: Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the skeletal muscle isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9D, also known as X-linked muscle glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. A pseudogene has been found on chromosome 1.,PHKA1,PHKA,Cancer,Signal Transduction,Kinase,Endocrine & Metabolism,Carbohydrate metabolism,Neuroscience,Calcium Signaling,PHKA1

Molecular Weight: 129kDa/135kDa/137kDa

Gene ID: 5255

UniProt: P46020

Pathways: Cellular Glucan Metabolic Process