PNN antibody (AA 1-100)

Catalog No. ABIN7269378

This anti-PNN antibody is a Rabbit Polyclonal antibody detecting PNN in WB. Suitable for Human.

Quick Overview for PNN antibody (AA 1-100) (ABIN7269378)

Target: PNN (Pinin, Desmosome Associated Protein (PNN))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PNN antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PNN Antibody

Binding Specificity: AA 1-100

Purpose: PNN Rabbit pAb

Sequence: MAVAVRTLQE QLEKAKESLK NVDENIRKLT GRDPNDVRPI QARLLALSGP GGGRGRGSLL LRRGFSDSGG GPPAKQRDLE GAVSRLGGER RTRRESRQES

Cross-Reactivity: Human, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PNN (NP_002678.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PNN

Target: PNN (Pinin, Desmosome Associated Protein (PNN))

Alternative Name: PNN

Background: Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene, the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.,PNN,DRS,DRSP,SDK3,memA,pinin,Epigenetics & Nuclear Signaling,Transcription Factors,RNA Binding,Cancer,Tumor suppressors,PNN

Molecular Weight: 67kDa/81kDa

Gene ID: 5411

UniProt: Q9H307