PDP antibody (AA 72-260)

Catalog No. ABIN7269774

The Rabbit Polyclonal anti-PDP antibody (ABIN7269774) specifically detects PDP in WB and IF. The antibody is reactive with Human samples.

Quick Overview for PDP antibody (AA 72-260) (ABIN7269774)

Target: PDP (Pyruvate Dehydrogenase Phosphatase (PDP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDP antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-PDP Antibody

Binding Specificity: AA 72-260

Purpose: PDP1 Rabbit pAb

Sequence: ASTPQKFYLT PPQVNSILKA NEYSFKVPEF DGKNVSSILG FDSNQLPANA PIEDRRSAAT CLQTRGMLLG VFDGHAGCAC SQAVSERLFY YIAVSLLPHE TLLEIENAVE SGRALLPILQ WHKHPNDYFS KEASKLYFNS LRTYWQELID LNTGESTDID VKEALINAFK RLDNDISLEA QVGDPNSFL

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 72-260 of human PDP1 (NP_060914.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PDP

Target: PDP (Pyruvate Dehydrogenase Phosphatase (PDP))

Alternative Name: PDP1

Background: Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported, one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.,PDP1,PDH,PDP,PDPC,PPM2A,PPM2C,PDP1

Molecular Weight: 61kDa/63kDa

Gene ID: 54704

UniProt: Q9P0J1