RRAGA antibody (AA 1-160)

Catalog No. ABIN7269878

The Rabbit Polyclonal anti-RRAGA antibody is suitable to detect RRAGA in samples from Human. It has been validated for WB and IHC.

Quick Overview for RRAGA antibody (AA 1-160) (ABIN7269878)

Target: RRAGA (Ras-Related GTP Binding A (RRAGA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RRAGA antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-RRAGA Antibody

Binding Specificity: AA 1-160

Purpose: RRAGA Rabbit pAb

Sequence: MPNTAMKKKV LLMGKSGSGK TSMRSIIFAN YIARDTRRLG ATIDVEHSHV RFLGNLVLNL WDCGGQDTFM ENYFTSQRDN IFRNVEVLIY VFDVESRELE KDMHYYQSCL EAILQNSPDA KIFCLVHKMD LVQEDQRDLI FKEREEDLRR LSRPLECACF

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human RRAGA (NP_006561.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for RRAGA

Target: RRAGA (Ras-Related GTP Binding A (RRAGA))

Alternative Name: RRAGA

Background: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death.,RRAGA,FIP-1,FIP1,RAGA,Epigenetics & Nuclear Signaling,Translation Control,Regulation of eIF4 and p70 S6 Kinase,Signal Transduction,G protein signaling,Signal Transduction,PI3K-Akt Signaling Pathway,mTOR Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Autophagy,Endocrine & Metabolism,Regulator of mTOR complex function,Regulators,RRAGA

Molecular Weight: 36kDa

Gene ID: 10670

UniProt: Q7L523