ARHGAP11B antibody (AA 218-267)

Catalog No. ABIN7269963

The Rabbit Polyclonal anti-ARHGAP11B antibody (ABIN7269963) specifically detects ARHGAP11B in WB. The antibody is reactive with Human samples.

Quick Overview for ARHGAP11B antibody (AA 218-267) (ABIN7269963)

Target: ARHGAP11B (rho GTPase Activating Protein 11B (ARHGAP11B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARHGAP11B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ARHGAP11B Antibody

Binding Specificity: AA 218-267

Purpose: ARHGAP11B Rabbit pAb

Sequence: EKKGVYQTLS WKRYQPCWVL MVSVLLHHWK ALKKVNMKLL VNIREREDNV

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 218-267 of human ARHGAP11B (NP_001034930.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ARHGAP11B

Target: ARHGAP11B (rho GTPase Activating Protein 11B (ARHGAP11B))

Alternative Name: ARHGAP11B

Background: Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis, thereby playing a key role in neocortex expansion. Promotes the proliferation of basal progenitors by inhibiting the mitochondrial permeability transition pore (mPTP: delays the opening of the mPTP via interaction with ADP:ATP translocase, thereby increasing mitochondrial Ca(2+ concentration and inducing glutamine catabolism, which is required for basal progenitor proliferation. Does not possess GTPase activator activity: the absence of GTPase activator activity is required to promote amplification of basal progenitors during neocortex development.,ARHGAP11B,FAM7B1,Signal Transduction,G protein signaling,Signal Transduction,ARHGAP11B

Molecular Weight: 30kDa

Gene ID: 89839

UniProt: Q3KRB8