SRRT antibody (AA 623-872)

Catalog No. ABIN7270253

The Rabbit Polyclonal anti-SRRT antibody has been validated for IHC. It is suitable to detect SRRT in samples from Human.

Quick Overview for SRRT antibody (AA 623-872) (ABIN7270253)

Target: SRRT (Serrate RNA Effector Molecule Homolog (SRRT))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SRRT antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-SRRT Antibody

Binding Specificity: AA 623-872

Purpose: SRRT Rabbit pAb

Sequence: DYYNTCEYPN EDEMPNRCGI IHVRGPMPPN RISHGEVLEW QKTFEEKLTP LLSVRESLSE EEAQKMGRKD PEQEVEKFVT SNTQELGKDK WLCPLSGKKF KGPEFVRKHI FNKHAEKIEE VKKEVAFFNN FLTDAKRPAL PEIKPAQPPG PAQSLTPGLP YPHQTPQGLM PYGQPRPPIL GYGAGAVRPA VPTGGPPYPH APYGAGRGNY DAFRGQGGYP GKPRNRMVRG DPRAIVEYRD LDAPDDVDFF

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 623-872 of human SRRT (NP_001122325.1).

Isotype: IgG

Application Details

Application Notes: IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SRRT

Target: SRRT (Serrate RNA Effector Molecule Homolog (SRRT))

Alternative Name: SRRT

Background: Acts as a mediator between the cap-binding complex (CBC and the primary microRNAs (miRNAs processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi by miRNAs. Binds capped RNAs (m7GpppG-capped RNA, however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity.,SRRT,ARS2,ASR2,serrate,Signal Transduction,Cell Biology & Developmental Biology,Endocrine & Metabolism,Drug metabolism,SRRT

Molecular Weight: 96kDa/100kDa

Gene ID: 51593

UniProt: Q9BXP5

Pathways: Notch Signaling, Stem Cell Maintenance