Shugoshin antibody (AA 10-100)

Catalog No. ABIN7270288

This Rabbit Polyclonal antibody specifically detects Shugoshin in WB and IF. It exhibits reactivity toward Human.

Quick Overview for Shugoshin antibody (AA 10-100) (ABIN7270288)

Target: Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Shugoshin antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-Shugoshin Antibody

Binding Specificity: AA 10-100

Purpose: SGOL1 Rabbit pAb

Sequence: SFQDSLEDIK KRMKEKRNKN LAEIGKRRSF IAAPCQIITN TSTLLKNYQD NNKMLVLALE NEKSKVKEAQ DIILQLRKEC YYLTCQLYAL K

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 10-100 of human SGOL1 (NP_612493.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Shugoshin

Target: Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))

Alternative Name: SGOL1

Background: The protein encoded by this gene is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID:18331714). Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life (PMID:25282101). Fibroblast cells from CAID patients exhibited both increased cell proliferation and higher rates of senescence. Pseudogenes of this gene have been found on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants.,SGO1,CAID,NY-BR-85,SGO,SGOL1,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Cell Cycle,Centromere,SGOL1

Molecular Weight: 24kDa/29kDa/31kDa/33kDa/35kDa/60kDa/64kDa

Gene ID: 151648

UniProt: Q5FBB7

Pathways: Maintenance of Protein Location